Hashirama's Cells
Episode 351 · Naruto Shippuden
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Filler or Canon?
No — Naruto Shippuden Episode 351 is filler. It's anime-original and has no impact on the main story. Safe to skip if you only want canon. A filler lore beat — Hashirama's cells and their harvested legacy; intriguing but non-canon and sealed off.NEXT CANON → SHP EP 362 · Kakashi's Resolve
Series
Naruto Shippuden
Episode
351 / 500
Status
Filler
Arc
4th War: Climax
4TH WAR: CLIMAX · EP 322–377 · 56 EPISODESYOU ARE HERE · 30 OF 56
Episode Summary
Hashirama's cells explores the First Hokage's biological legacy within the filler arc, the cells that grant Wood Style and that Orochimaru harvested for his experiments. The episode develops the anime-original backstory — Hashirama's unique power, its theft and replication, the threads connecting it to Tobi, Yamato and the war. Sealed inside its filler frame, it expands lore loosely without canon weight. Competent and intriguing, Hashirama's cells are engaging in their bubble and outside the timeline, a diversion deepening the world's power-history.
Frequently Asked
What arc is it in?
It's part of the 4th War: Climax arc.
Can I skip it?
Yes, you can safely skip it without missing main story.
4th War: Climax · Ep 322–377 · 56 episodes
322Madara UchihaS+Manga Canon323The Five Kage AssembleManga Canon324The UnmaskingMixed Canon/Filler325Jinchuriki vs. Jinchuriki!Manga Canon326Four Tails, the King of Sage MonkeysManga Canon327Nine-TailsMixed Canon/Filler328KuramaMixed Canon/Filler329Two-Man TeamBManga Canon330The Promise of VictoryMixed Canon/Filler331Eye in the DarkMixed Canon/Filler332A Will of StoneManga Canon333The Risks of the Reanimation JutsuManga Canon334Sibling Tag TeamManga Canon335Everyone is a CloudManga Canon336Yakushi Kabuto, Rogue NinjaBManga Canon337The IzanagiManga Canon338The IzanamiMixed Canon/Filler339I Will Always Love YouManga Canon340Edo Tensei: Release!Manga Canon341Orochimaru ReturnsManga Canon342The Secret of the Transportation JutsuManga Canon343Who Are You?Manga Canon344Senju and UchihaManga Canon345I'm in HellS+Manga Canon346World of DreamsMixed Canon/Filler347Creeping ShadowFiller348New AkatsukiFiller349A Mask That Hides the HeartFiller350Minato's DeathFiller
351Hashirama's CellsFiller
352The Rogue Ninja OrochimaruFiller353Orochimaru's Test SubjectAFiller354Their Own PathsFiller355The Targeted SharinganFiller356A Shinobi of the LeafBFiller357An ANBU UchihaFiller358Coup d'ÉtatBFiller359The Tragic NightFiller360The Jonin SquadFiller361Team 7's First MissionFiller362Kakashi's ResolveMixed Canon/Filler363The Allied Shinobi Forces JutsuAManga Canon364What Fills the HoleManga Canon365Those Who Dance in the ShadowsManga Canon366The All-KnowingManga Canon367Hashirama Senju, the Ultimate ShinobiManga Canon368Era of Warring StatesManga Canon369My True DreamManga Canon370Sasuke's AnswerManga Canon371HoleManga Canon372Something to Fill the HoleManga Canon373Team 7, Assemble!Manga Canon374The New Three-Way DeadlockManga Canon375Kakashi vs. ObitoS+Manga Canon376The Directive to Take the Nine-Tails!Filler377Naruto vs. Mecha NarutoFiller720 episodes — canon, mixed, filler and best animation moments.
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